Allograft Rejection?

     Much like an organ transplant, Human Tissue Cellular Allografts are a type of transplant, however there is no chance of rejection. This has to do with the source of where the cells/organ comes from. Organ transplants are donated from another human, so it has immune cells attached to it that are very specific to their human source. This is why organ transplants are best used when donated by someone in your own family, so at least there is some low level amount of recognition. Despite this, all organ transplant recipients must use immune suppressant drugs to prevent their body from rejecting the new organ.

     The human tissue cellular allografts we used in regenerative medicine come from the human placenta and the outer layer of the umbilical cord. The cells extracted from these tissues are immune neutral; they have no immune cells. This is why when you transplant these live cells into the body for treatment, there is no chance of rejection. In our office, human tissue cellular allografts are mostly used for intra-articular treatment (directly into a damaged joint), but can also be used systemically through intra-venous infusion without any fear of rejection.